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Attitudes and awareness of genetic testing for BRCA genes in women in Czechia
 Nejedlová, Pavlína ; Kulhánová, Ivana (advisor) ; Hirsch, Ivan (referee)
The thesis deals with the issue of awareness and attitudes of women towards genetic testing for BRCA genes in Czechia. Genetic testing reveals hereditary predispositions of BRCA1 and BRCA2 gene mutations, which are associated with a high risk of hereditary cancers, especially breast and ovarian cancer. The thesis focuses on the importance of genetic testing, which can help to identify women at high risk of developing these diseases and to inform them sufficiently about appropriate preventive measures or recommendations for early treatment. Awareness and genetic counselling are important factors for individuals and their family members. Genetic mutations in the BRCA1 and BRCA2 genes are estimated to account for 5-10% of all breast and ovarian cancers. In this study, the association between social determinants and awareness of genetic testing is examined to determine whether these determinants are important in women's access to and awareness of testing. The analysis used data from 911 respondents who participated in the Sociological Survey of Citizens of the Czech Republic, a sample survey provided by the INRES agency. The binary logistic regression method was used to analyze the relationship between awareness of BRCA genetic testing and the attitude of women in Czechia towards undergoing such...
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